Hello,
I am operating a relay via the GPIO16(D0) pin of the Wemos D1 Mini board. I have made a relay optocoupler driver circuit (Fig 1). The main problem is that GPIO16 is HIGH at boot. To tackle the issue, I made another circuit and simulated it in Proteus (Fig 2). Relay activates when the signal is Low and deactivates when the signal is High. Will this solution work? I am a bit new to it. I am attaching both the figures.

 

Will this solution work?

No.
Configure like this:

 

Configure like this:

Relay activates when the signal is Low and deactivates when the signal is High.

sghioto, your circuit does the opposite.

 

Is it possible to use other GPIO pins like, GPIO4, GPIO5, GPIO12, GPIO13, GPIO14?
They are low at boot

 

sghioto, your circuit does the opposite.

How so?

 

Looks to me like it's the original circuit that doesn't match the text.

 

How so?

I posted his request in my post #3.
Is that not clear?

 

I posted his request in my post #3.
Is that not clear?

My modification activates the relay when D0 is low as the TS requested.
What is not clear about the circuit?

 

My modification activates the relay when D0 is low as the TS requested.

Mea culpa.
I missed the inversion on the LED input.

 

If there is a problem with it not working, measure the voltage between the base and th emitter when the relay is supposed to operate. It may be that the opto-isolator LED is not getting enough drive current.