I was wondering if its common to produce square waves from the HV507 output. I dont mean by using two outputs and creating a differential driven square wave, but actually swapping what gets inputted into the HV supply rails (vpp and hvgnd). For instance, to produce the 300v swing we would supply vpp with 300v and hvgnd to the gnd, but for the -300v swing, we would input 300v into hvgnd and gnd to vpp. Is this ok or are there any better ways to produce a square wave via one hv507 output?

 

With Vpp at -300V you will exceed the 'absolute maximum, ratings' which give Vdd < Vpp < 320V, where -0.6 < Vdd < 6V.

I expect that the separate HVgnd is to cater for high output switching currents, rather than being isolated from logic ground.