I think it would only take a minor disruption, like 10 years, to lose some of the specialized functions like IC fabrication or DNA sequencing. Personally, I can't imagine how to build an oil refinery or start with iron ore and make several grades of steel.the next generation can't figure out how to keep the lights burning,
One of my friends was a structural engineer. When he retired I made a comment about letting that Calculus bump on his brain atrophy. He said it atrophied a long time ago. An entire career in structural engineering and he forgot Calculus a long time ago?how many people will actually benefit from learning calculus? Maybe 5% of those exposed to it, and maybe only 0.5%.