I have designed and assembled a 4-channel mPCIe card implemented around a FTDI FT4232H. The basis of the design is to allow communication over RS232 with up to four different microcontrollers with corresponding RS232 to TTL converters. The card will be mated to a Ventana GW5220. However, when I plugged it in for the first time something in the FT4232H mush have shorted, because it got hot enough to burn my finger in a matter of seconds. I have made many attempts to determine the cause of the short but I have had no luck so far. I would greatly appreciate any assistance with debugging this design.
Things I have tried:
- Checked all datasheed pinouts against land patterns and schematic symbols (including the mPCIe card connector) multiple times
- Checked all part numbers for errors multiple times
- Examined board post-short under a microscope for charring or visible solder bridges and found no evidence of either
- Attempted to power the board post-short with a current-limited power supply to check voltages on pins and found that the FT4232H's on-board 1.6V regulator is toast
- Checked the mPCIe standard to ensure that the voltage limits for the +3.3V output are within the limits that the FT4232H can accept, and they are
Here is the schematic (click for larger):

Here is an image of the board design (click for larger):

And an image of the assembled board (click for larger):

Things I have tried:
- Checked all datasheed pinouts against land patterns and schematic symbols (including the mPCIe card connector) multiple times
- Checked all part numbers for errors multiple times
- Examined board post-short under a microscope for charring or visible solder bridges and found no evidence of either
- Attempted to power the board post-short with a current-limited power supply to check voltages on pins and found that the FT4232H's on-board 1.6V regulator is toast
- Checked the mPCIe standard to ensure that the voltage limits for the +3.3V output are within the limits that the FT4232H can accept, and they are
Here is the schematic (click for larger):

Here is an image of the board design (click for larger):

And an image of the assembled board (click for larger):
