Thanks!Multisim is about as far as you can get from free. $5k for the full edition.
It's built to be integrated with LabVIEW which is also far from free.
It uses slightly different simulation engine, but LTSpice is easy to use once you add enough models manually from the Spice group download.
MultiSim comes with UltiBoard, a PCB Routing utility that is pretty decent, supporting lots of layers, though hand routing is generally faster for small circuits, even on a fast machine (for reasons given above).
Each sim has their own pros and cons, but LTSpice is the best free simulator around. The ease of plotting outputs by clicking is nice. In multisim, an oscilloscope or function generator need to be connected as a physical one would, but then you have a realtime adjustment of both function gen and scope while simulation is running. In LTSpice, adding sweep steps and plotting the output is the closest it can come to the same functionality. The real "instruments" and realtime modification of signals, in addition to PIC MCU hex code runtime simulation (Which Proteus, another non-free tool offers), boost the cost a good deal.
I tend to stick with a single simulator/layout editor/schematic capture/etc. when I design, I've been meaning to check some other ones out for times I talk with others, but haven't gotten around to it yet.
I'm wondering how all of the Indian students that can't figure out how to flash a LED can afford both Proteus and Multisim..