Coronavirus?!

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nsaspook

Joined Aug 27, 2009
16,325
https://www.nature.com/articles/s41586-021-03777-9
The SARS-CoV-2 B.1.617 lineage was identified in October 2020 in India1–5. It has since then become dominant in some indian regions and UK and further spread to many countries6. The lineage includes three main subtypes (B1.617.1, B.1.617.2 and B.1.617.3), harbouring diverse Spike mutations in the N-terminal domain (NTD) and the receptor binding domain (RBD) which may increase their immune evasion potential. B.1.617.2, also termed variant Delta, is believed to spread faster than other variants. Here, we isolated an infectious Delta strain from a traveller returning from India. We examined its sensitivity to monoclonal antibodies (mAbs) and to antibodies present in sera from COVID-19 convalescent individuals or vaccine recipients, in comparison to other viral strains. Variant Delta was resistant to neutralization by some anti-NTD and anti-RBD mAbs including Bamlanivimab, which were impaired in binding to the Spike. Sera from convalescent patients collected up to 12 months post symptoms were 4 fold less potent against variant Delta, relative to variant Alpha (B.1.1.7). Sera from individuals having received one dose of Pfizer or AstraZeneca vaccines barely inhibited variant Delta. Administration of two doses generated a neutralizing response in 95% of individuals, with titers 3 to 5 fold lower against Delta than Alpha. Thus, variant Delta spread is associated with an escape to antibodies targeting non-RBD and RBD Spike epitopes.
Vaccines work much better against Delta than immunity from natural infection.

https://www.smh.com.au/world/europe...y-inhibits-delta-variant-20210709-p58885.html
The research has been released as Pfizer seeks US authorisation for a third dose of its COVID-19 vaccine, saying that another shot within 12 months could dramatically boost immunity and maybe help ward off new coronavirus mutations.

On Thursday, Pfizer’s Dr Mikael Dolsten told The Associated Press that early data from the company’s booster study suggests people’s antibody levels jump five- to 10-fold after a third dose, compared to their second dose months earlier.
 

cmartinez

Joined Jan 17, 2007
8,763

One dose of an inhaled COVID-19 vaccine showed success in animal studies, researchers say, possibly opening the door for another option that’s easier to administer than the traditional needle shots. The vaccine, dubbed PIV5, was developed using a platform previously used for influenza vaccines and targets mucosal cells that line the nasal passages and airways
 
Virus mutations begin inside fools who are not vaccinated and who live long enough to pass the virus around.
When all the fools die then normal people can act normal again.
If the fools are executed then maybe we will not need a 3rd dose.
 

Reloadron

Joined Jan 15, 2015
7,890
Virus mutations begin inside fools who are not vaccinated and who live long enough to pass the virus around.
When all the fools die then normal people can act normal again.
If the fools are executed then maybe we will not need a 3rd dose.
Maybe we could just execute the arrogant and pompous and be done with it? Would that work for you? While I can't speak for your center of the universe in my little part of the world I support the rights of those who prefer not to be vaccinated. My wife and I have been vaccinated so why worry about it but that does not mean I would call those who choose not to be fools while I may call the arrogant who choose to make a comment like that a fool.

Thank You and Have a Nice Day
Ron
 

shortbus

Joined Sep 30, 2009
10,050
@Reloadron So it's your thinking that just let the experiment run it's course? Is that what should have happened back in the 50's with polio?

Not making sure that most everyone is vaccinated for this covid or any of the life changing viruses just make it an experiment in how far the virus can mutate. And mutate it will. When only some in a community are vaccinated and other not, it will mutate to the point that it will again start killing those that are vaccinated.

You were in the service, did you get a choice as to whether you got vaccinated? Did getting those jabs take away any of your freedoms? Did they keep you from getting the infections prevalent in where you were being sent?

Personally I see not mandating vaccination as the wrong side of freedom.
 

Reloadron

Joined Jan 15, 2015
7,890
@Reloadron So it's your thinking that just let the experiment run it's course? Is that what should have happened back in the 50's with polio?

Not making sure that most everyone is vaccinated for this covid or any of the life changing viruses just make it an experiment in how far the virus can mutate. And mutate it will. When only some in a community are vaccinated and other not, it will mutate to the point that it will again start killing those that are vaccinated.

You were in the service, did you get a choice as to whether you got vaccinated? Did getting those jabs take away any of your freedoms? Did they keep you from getting the infections prevalent in where you were being sent?

Personally I see not mandating vaccination as the wrong side of freedom.
No my thinking is not to call those who disagree with my thinking fools. While my wife and I did get vaccinated I will defend the rights of those who refuse. Additionally if I have been vaccinated why should I care what my neighbor chooses to do. When I was in the service I signed an enlistment contract which means the service pretty much had control of my life and I agreed to that. I simply do not feel people should be forced to be vaccinated nor do I feel they should be labeled fools simply because their thinking does not align with mine. I just do not see mandating vaccine as a good idea but more important I won't call those who choose to refuse fools. With that in mind should they contract COVID they can suffer the consequences of their decision. Having been vaccinated why should I care what the next person does? Then too, already the government is coming out saying that maybe an additional booster may be necessary. I really don't place much stock in what government says and even within government there is conflicting data.

In summary I view pompous and arrogant statements like those made by Audio Guru as petty and foolish lending to those who make those statements as the real fools. So much for tolerance huh? Then too we can't all live in the center of the universe. :)

Ron
 

Reloadron

Joined Jan 15, 2015
7,890
does this come down to Star Trek ?

Well maybe yes and maybe no. Since I am sitting here in Ohio, Cleveland suburbs I guess Ohio will do. Currently accordingly to the Ohio Department of Public Health only 48.16% of population has vaccine started so that means 51.84% have not even gotten the first dose or any dose at all. So the majority of population has not been vaccinated. Ohio Vaccination Dashboard. Things get more interesting when a breakdown is done by county is done. Anyway as can be seen Ohio is under 50% vaccinated or half the population. Not sure how things stack up on a national basis and really not sure what or which numbers can be trusted. :)

Ron
 
The other side of the needs of the many outweigh the needs of the few is...

Protecting the minority from the tyranny of the majority.

Of course how those ideas relate to public health is open to debate.

I believe that everyone should get vaccinated, but I'm also against forcing people.

I mean...what the hell are we going to do...send out vaccination squads to invade peoples homes and force the vaccine on them?

Fines?

Ostracization?

Welcome to dystopia.
 

djsfantasi

Joined Apr 11, 2010
9,237
In a global pandemic, there are no rights to refuse a vaccination.

Your rights can not trample on the rights of others. And refusing a vaccine does so by putting others at risk. Look at the US. Current Covid cases occur 99+% of the time in the unvaccinated population. The only valid excuse is a medical one. And even then in order to protect the rights of others, while vaccinations of any sort are contraindicated by my health condition, I chose to get vaccinated. I do not get measles, shingles, flu and other vaccines. For they could be a death sentence for me.

Those states with the lowest levels of vaccination are experiencing another spike in cases, hospitalizations and deaths. You cannot enjoy your rights if you’re permanently disabled or even dead.

This is the UNITED States of America. Each citizen has a duty to the country which supersedes personal interest. Or the other way, putting personal interests first is undemocratic and dangerous to the Republic.
The other side of the needs of the many outweigh the needs of the few is...

Protecting the minority from the tyranny of the majority.

Of course how those ideas relate to public health is open to debate.

I believe that everyone should get vaccinated, but I'm also against forcing people.

I mean...what the hell are we going to do...send out vaccination squads to invade peoples homes and force the vaccine on them?

Fines?

Ostracization?

Welcome to dystopia.

Protecting the minority from the tyranny of the majority is a non-existent issue in a Democratic or modern society. Operating under the principle that personal interests are greater than society’s interests possibly could justify your position. However, that position is invalid in modern society. Perhaps if we were still Neanderthals…

Any successful society disregards the concept of personal rights, WHEN it harms others or impinges on others personal beliefs.

What you propose may give me permission to take an AK-47 and shoot all non-vaccinated people. Because of course, they are impinging on my personal beliefs.

That would protect my rights and solve the problem.
 
" What you propose may give me permission to take an AK-47 and shoot all non-vaccinated people. Because of course, they are impinging on my personal beliefs. "

I never proposed any such thing.

I also never said anything about "personal rights".

So put your money where your mouth is dj and tell me what you would do to get everyone vaccinated, including those who refuse?
 
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justtrying

Joined Mar 9, 2011
439
In a global pandemic, there are no rights to refuse a vaccination.

Your rights can not trample on the rights of others. And refusing a vaccine does so by putting others at risk. Look at the US. Current Covid cases occur 99+% of the time in the unvaccinated population. The only valid excuse is a medical one. And even then in order to protect the rights of others, while vaccinations of any sort are contraindicated by my health condition, I chose to get vaccinated. I do not get measles, shingles, flu and other vaccines. For they could be a death sentence for me.

Those states with the lowest levels of vaccination are experiencing another spike in cases, hospitalizations and deaths. You cannot enjoy your rights if you’re permanently disabled or even dead.

This is the UNITED States of America. Each citizen has a duty to the country which supersedes personal interest. Or the other way, putting personal interests first is undemocratic and dangerous to the Republic.



Protecting the minority from the tyranny of the majority is a non-existent issue in a Democratic or modern society. Operating under the principle that personal interests are greater than society’s interests possibly could justify your position. However, that position is invalid in modern society. Perhaps if we were still Neanderthals…

Any successful society disregards the concept of personal rights, WHEN it harms others or impinges on others personal beliefs.

What you propose may give me permission to take an AK-47 and shoot all non-vaccinated people. Because of course, they are impinging on my personal beliefs.

That would protect my rights and solve the problem.
You are very brave to take this vaccine if all of the established ones spell the death of you.

Many people may choose not to take it for many reasons. Health may be one of them. In a democratic society you are not to question their decisions or to spy on your neighbor. You took the vaccine, you are protected.
I find that lately people are too busy monitoring others.

Vaccines will also prolong our misery, we are now exerting pressure on the virus to survive so that should be interesting. Smallpox and polio were "eradicated" largely because they can only exist in a human host.
 

shortbus

Joined Sep 30, 2009
10,050
Smallpox and polio were "eradicated" largely because they can only exist in a human host.
And just what was used to do that eradication? We live in a different world now even since that eradication took place. The global economy took care of that. People fly in and out of countries now that were once isolated from each other.

And as long as there is a place and people for the covid to mutate from it will get stronger and more infectious. Just look at how it's going now and extrapolate from that to a few years from now. The ignorant propaganda that is being met as gospel is just astounding to me.

Wish I could really say what I mean about where this vaccine hesitancy is coming from, but if I do I'll get banned from the thread. The least political way is to just say, the people/party that was pushing for the vaccine to be done fast has now changed it's positions on it's use. Those that were for it are now against it.
 
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