Coronavirus?!

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nsaspook

Joined Aug 27, 2009
16,325
https://www.studyfinds.org/covid-19-rattlesnake-venom/
COVID-19 appears to kill patients in the same way a rattlesnake does — triggering a protein related to neurotoxins found in the reptile’s venom, a new study reveals. Scientists at the University of Arizona believe the mechanism may hold the key to predicting patients most likely to die from the virus.

This trigger fuels the severity of the virus by causing severe inflammation. A patient’s immune system goes into overdrive, leading to organ failure.
https://www.jci.org/articles/view/149236
There is an urgent need to identify cellular/molecular mechanisms responsible for severe COVID-19 progressing to mortality. We initially performed untargeted/targeted lipidomics and focused biochemistry on 127 plasma samples and found elevated metabolites associated with secreted phospholipase A2 (sPLA2) activity and mitochondrial dysfunction in severe COVID-19 patients. Deceased COVID-19 patients had higher levels of circulating, catalytically active sPLA2 Group IIA (sPLA2-IIA), with a median value 9.6-fold higher than mild patients and 5.0-fold higher than severe COVID-19 survivors. Elevated sPLA2-IIA levels paralleled several indices of COVID-19 disease severity (e.g., kidney dysfunction, hypoxia, multiple organ dysfunction). A decision tree generated by machine learning identified sPLA2-IIA levels as a central node in stratifying patients that succumbed to COVID-19. Random forest analysis and LASSO-based regression analysis additionally identified sPLA2-IIA and blood urea nitrogen (BUN) as the key variables among 80 clinical indices in predicting COVID-19 mortality. The combined PLA-BUN index performed significantly better than either alone. An independent cohort (n=154) confirmed higher plasma sPLA2-IIA levels in deceased patients vs. severe or mild COVID-19, with the PLA-BUN index-based decision tree satisfactorily stratifying mild, severe, and deceased COVID-19 patients. With clinically tested inhibitors available, this study supports sPLA2-IIA as a therapeutic target to reduce COVID-19 mortality.
 

nsaspook

Joined Aug 27, 2009
16,325
http://www.koreaherald.com/view.php?ud=20210824001023
The fourth surge in infections has placed Greater Seoul under the most stringent tier of social distancing -- which bans social gatherings of more than two people past 6 p.m. and shuts down food outlets and other risky places at night -- since the first week of July.

A recent report out of Seoul National University’s preventive medicine department suggested the measures currently in place have been ineffective in containing the latest surge. The weekslong intensive social distancing, the report said, was not leading to decline in movement.

“Korea’s pandemic control strategy has relied on people willingly following safety steps, without imposing a lockdown or travel restriction. But the compliance appears to be waning,” said Dr. Jung Ki-suck, former chief of the Korea Centers for Disease Control and Prevention.
 

nsaspook

Joined Aug 27, 2009
16,325
https://www.wsj.com/articles/biden-...rs-at-six-months-instead-of-eight-11629919356
Federal regulators are likely to approve a Covid-19 booster shot for vaccinated adults starting at least six months after the previous dose rather than the eight-month gap they previously announced, a person familiar with the plans said, as the Biden administration steps up preparations for delivering boosters to the public.

Data from vaccine manufacturers and other countries under review by the Food and Drug Administration is based on boosters being given at six months, the person said. The person said approval for boosters for all three Covid-19 shots being administered in the U.S.—those manufactured by Pfizer Inc. and partner BioNTech SE, Moderna Inc. and Johnson & Johnson —is expected in mid-September.
The Biden administration and companies have said that there should be enough supply for boosters that they plan to begin distributing more widely on Sept. 20. The U.S. has purchased a combined 1 billion doses from Pfizer and Moderna.
https://news.yahoo.com/u-data-show-rising-breakthrough-181525317.html
The CDC is relying on data from cohorts, such as the Los Angeles County study, to determine whether Americans need a third dose of COVID-19 vaccines to increase protection. Government scientists last week laid out a strategy for booster doses beginning on Sept. 20, pending reviews from the U.S. Food and Drug Administration and the CDC.

The new data released on Tuesday involved more than 43,000 reported infections among Los Angeles County residents aged 16 and older. Of them, 10,895, or 25.3%, occurred in fully vaccinated persons, 1,431, or 3.3%, were in partially vaccinated persons, and 30,801, or 71.4%, were in unvaccinated individuals.

The vaccines did, however, protect individuals from more severe cases. According to the study, 3.2% of fully vaccinated individuals who were infected with the virus were hospitalized, just 0.5% were admitted to an intensive care unit and 0.2% were placed on a ventilator.
 

nsaspook

Joined Aug 27, 2009
16,325
https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1
Background: Reports of waning vaccine-induced immunity against COVID-19 have begun to surface. With that, the comparable long-term protection conferred by previous infection with SARS-CoV-2 remains unclear. Methods: We conducted a retrospective observational study comparing three groups: (1)SARS-CoV-2-naive individuals who received a two-dose regimen of the BioNTech/Pfizer mRNA BNT162b2 vaccine, (2)previously infected individuals who have not been vaccinated, and (3)previously infected and single dose vaccinated individuals. Three multivariate logistic regression models were applied. In all models we evaluated four outcomes: SARS-CoV-2 infection, symptomatic disease, COVID-19-related hospitalization and death. The follow-up period of June 1 to August 14, 2021, when the Delta variant was dominant in Israel. Results: SARS-CoV-2-naive vaccinees had a 13.06-fold (95% CI, 8.08 to 21.11) increased risk for breakthrough infection with the Delta variant compared to those previously infected, when the first event (infection or vaccination) occurred during January and February of 2021. The increased risk was significant (P<0.001) for symptomatic disease as well. When allowing the infection to occur at any time before vaccination (from March 2020 to February 2021), evidence of waning natural immunity was demonstrated, though SARS-CoV-2 naive vaccinees had a 5.96-fold (95% CI, 4.85 to 7.33) increased risk for breakthrough infection and a 7.13-fold (95% CI, 5.51 to 9.21) increased risk for symptomatic disease. SARS-CoV-2-naive vaccinees were also at a greater risk for COVID-19-related-hospitalizations compared to those that were previously infected. Conclusions: This study demonstrated that natural immunity confers longer lasting and stronger protection against infection, symptomatic disease and hospitalization caused by the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity. Individuals who were both previously infected with SARS-CoV-2 and given a single dose of the vaccine gained additional protection against the Delta variant.
As expected the human body is an incredible machine. Every adult that hasn't been infected greatly benefits from vaccination but the case for mandatory vaccination for young children IMO is weaker if this is true. Natural infection should be more protective when the next major variant escapes the current vaccines.

This sounds like bad news for countries like New Zealand, Australia etc. They tried really hard to suppress but now it looks like vaccination won't be enough, they need to keep certain restrictions in place and maybe require more boosters until the world is 'safe'.

In the US it's actually advantageous now for the fully vaccinated to get a mild infection from delta as a natural booster for future variants. Vaccinate as many people as possible (to reduce hospitalizations and deaths) while allowing the now-protected people to catch the virus to build up their immunity to new variants.
 
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nsaspook

Joined Aug 27, 2009
16,325
https://www.cnbc.com/2021/08/26/us-...f-slowing-even-as-fatalities-surge-again.html
Covid cases are still on the rise in the U.S., but the pace of infections is showing signs of slowing, especially in some of the states that have been hit hardest by the delta variant.
...
Though slowing case counts may indicate that the delta surge is finally approaching its apex, many states still face a flood of hospitalizations and deaths. The 139 deaths reported in Louisiana on Aug. 24 is the highest single-day total over the course of the pandemic, according to Johns Hopkins data.
 

nsaspook

Joined Aug 27, 2009
16,325
https://www.publichealth.columbia.e...ews/one-three-americans-had-covid-19-end-2020
One in Three Americans Already Had COVID-19 by the End of 2020
UNDOCUMENTED INFECTIONS ACCOUNTED FOR ESTIMATED THREE-QUARTERS OF INFECTIONS LAST YEAR
Anew study published in the journal Nature estimates that 103 million Americans, or 31 percent of the U.S. population, had been infected with SARS-CoV-2 by the end of 2020. Columbia University Mailman School of Public Health researchers modeled the spread of the coronavirus, finding that fewer than one-quarter of infections (22%) were accounted for in cases confirmed through public health reports based on testing.
The study is the first to comprehensively quantify the overall burden and characteristics of COVID-19 in the U.S. during 2020. The researchers simulated the transmission of SARS-CoV-2 within and between all 3,142 U.S. counties using population, mobility, and confirmed case data.
 

bertus

Joined Apr 5, 2008
22,925
A sheep farmer stuck in lockdown in New South Wales who was unable to attend his aunt’s funeral has honoured her memory with the ultimate tribute:
a love heart made from sheep. Ben Jackson from Guyra couldn’t make it to Brisbane to be with his aunt during her final moments after a two-year fight with cancer that began at the start of the pandemic:

 

SamR

Joined Mar 19, 2019
5,491
More and more reports from exasperated Physicians and other health care hospital personnel upset with being overworked by what they consider "Self Inflicted" hospitalizations by non-vaccinated patients. Just can't overestimate stupidity I guess... As I said before, lots of Darwin Award winners. Ga. Governor has called out the State National Guard medical personnel (probably removing them for their normal day jobs at hospitals) to deal with the current huge uptick in Covid hospitalizations and lack of sufficient staff. Kinda like robbing Peter to pay Paul as I see it. Local reports are that our local area is now the No. 1 hotspot in the US. No surprise to me, masking regulations dropped and only 33% of our local population Vaxed. They have required masking and distancing (although only nominally enforced) in the health care facilities that I have had to visit but nowhere else.
 
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Reloadron

Joined Jan 15, 2015
7,890
This guy knew what he was talking about. But he can't talk now.
https://news.yahoo.com/texas-anti-mask-freedom-rally-045722778.html
Sometimes we learn too late about things. Through life we all make decisions and sometimes really poor decisions. Then we have to live with our decisions be they good or poor. Oh well if Caleb dies at 30 due to a poor life decision he is a victim of not just COVID but himself. Based on his wife's statements and his condition I suggest she start learning to live life less him.

Ron
 

Reloadron

Joined Jan 15, 2015
7,890
Also, one local Covid related death of a young man, he didn't die from Covid but from Ivermectin poisoning after taking a horse dose of it from Tractor Supply to treat himself.
Sheese, everyone knows you should take a small pony dose not a full horse dose.

Self medicating one's self is nota good idea. Whenever I see a doctor my first question always is "you went to school for this, right"?

Ron
 

killivolt

Joined Jan 10, 2010
836
Sheese, everyone knows you should take a small pony dose not a full horse dose.
Ron
lol, ya at the very least should have seen a Doctor, Ahem, I mean a Vet, at least he would have received the proper dose.

I know I’m an animal but, geez these people are taking it a bit to far, somebody call an animal rights lawyer, they shouldn’t be allowed in the feed store By themselves.

kv
 
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