Hi everyone!
I'm not sure if this is the best place to ask this question, but I'll give it a try.
So, I'm facing a quite complex problem, that I will try to summarize here, and I would like to hear any ideas on how I can possibly get around it.
I have recordings of 2 different signals: in particular one is a recording of current passing through an electrode and the other is a recording of fluorescence intensity recorded with a CCD camera. These recordings can be as long as 1 or 2 hours and, for technical reasons, have to be recorded at different rates, in particular 1Hz for the fluorescence and 1kHz for the current.
Now, in some occasions there are definite events in these signals, seen as transient increases in the fluorescence or in the current. I want to see if the times when these event happens are the same or not. Just by looking at the traces I would say that this is almost always the case, but I would like to have an automatic procedure to do that.
Any idea of how to solve this problem? I was reading about correlation functions, would that be of any help to me? And do the different sampling rates represent a problem?
Also, to make things more complicated... the two types of increases are different. While the fluorescence just increases, stays high for 5-10 seconds and then goes down, the electrical signal has only very quick spikes during that period (say, 50-100 spikes during those 5-10 seconds).
Well, I hope all of this makes some sense to you guys, and that you can give me some ideas!
Thank you a lot
nico
I'm not sure if this is the best place to ask this question, but I'll give it a try.
So, I'm facing a quite complex problem, that I will try to summarize here, and I would like to hear any ideas on how I can possibly get around it.
I have recordings of 2 different signals: in particular one is a recording of current passing through an electrode and the other is a recording of fluorescence intensity recorded with a CCD camera. These recordings can be as long as 1 or 2 hours and, for technical reasons, have to be recorded at different rates, in particular 1Hz for the fluorescence and 1kHz for the current.
Now, in some occasions there are definite events in these signals, seen as transient increases in the fluorescence or in the current. I want to see if the times when these event happens are the same or not. Just by looking at the traces I would say that this is almost always the case, but I would like to have an automatic procedure to do that.
Any idea of how to solve this problem? I was reading about correlation functions, would that be of any help to me? And do the different sampling rates represent a problem?
Also, to make things more complicated... the two types of increases are different. While the fluorescence just increases, stays high for 5-10 seconds and then goes down, the electrical signal has only very quick spikes during that period (say, 50-100 spikes during those 5-10 seconds).
Well, I hope all of this makes some sense to you guys, and that you can give me some ideas!
Thank you a lot
nico