I have always powered using a 12V supply and 12V to 3.3V linear regulator. My latest design got pretty dam hot....so I am guessing going 12V to 3.3V is not the greatest idea if you are actually using all 100 or so pins. It still worked, but the regulator was pretty dam hot to the touch. In general, was going from 12V to 3.3V directly a bad idea? I have used a switcher to 5V, then an LDO to 3.3V, but I only do that when I actually need to use 5V for something.