I don't understand those 12 volt power supplies and no they do not look correct. You have 12 volt batteries strung across the ICs and no power supply reference to ground.
While I don't use Proteus I would try something like the above for +/- 12 Volts.
To elaborate on what Reloadron said, your circuit is trying to source and sink current through loads connected to ground but the power supply is not grounded.