Yes, it can simplify any subsequent math used to process the signal.
In some applications is convenient to have have 1LSB equal to a nice even voltage.That sounds like it simplifies characterizing the device, but for normal use? Why would it matter if 1 LSB is 1.000mV or 1.1mv? Either way it's the same digital output value.
It's far easier perform calculations when interfacing an ADC referenced to that voltage to an MCU. Especially when dealing with assembly code and when very fast conversion rates are needed.That sounds like it simplifies characterizing the device, but for normal use? Why would it matter if 1 LSB is 1.000mV or 1.1mv? Either way it's the same digital output value.
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