A real device has a wide range of specs from minimum to maximum. You do not know the specs of the device you buy unless you test it.
A simulation uses only "typical" specs and if you build the circuit with devices that has minimum or maximum specs then some of them Will not Work!
You need to use engineering to design a circuit that works properly with a device that has minimum to maximum specs.
Then every circuit made will work.
I should have said, "A device that has a wide range of specs from minimum for some to maximum for some".
If the Mosfet is simply used as an on-off switch then maybe it is OK if it barely turns on.
This gets to the fundamental purpose of simulation, which is understanding. If you are using simulation for design verification, you may want to consider multiple alternative approaches.