The 8:1 muxes select channel 0-15 and produce two outputs.
You then select the right mux using the 2:1 mux.
If you must use 8:1 muxes then with the last mux only two channels are used and only one select bit is used.
Actually there may be a way to use two 8:1 muxes, if they have a chip select. However, you will need to implement external logic to select the first or second mux.
It can't be done using two 8-input multiplexers alone. Depending on the type of 8-input multiplexer, some other logic will also be needed.
The circuit attached shows how two multiplexers with "3-state" outputs (that can be made open-circuit using an enable input) can be combined using an additional inverter.
The output goes open-circuit when the /EN input is high.