K-maps of up to six variables are very straight-forward to work with after just a bit of practice. You just have four stacked 4-variable K-maps -- they are usually written side by side but you visualize them as forming a cube.
Why do you need some piece of software to do your thinking for you? If you are already conversant with the techniques and are just using the software to do the grunt work, that's one thing. But if you are "needing" the software because you can't do the grunt work, then you've got a problem.